Increased activation of the PAM pathway is frequent in breast cancer (BC) and is often (>30%) associated with alterations of PAM pathway genes, such as activating mutations or amplification of PIK3CA, which encodes the PI3Kα catalytic subunit, or loss of function of PTEN, which is the main negative regulator of the PAM pathway [4]. The gene discussed is PIK3CA; the disease is breast carcinoma.