For instance, the elevated expression of VEGF receptors (e.g., FLT1 and FLT4) in BECs correlates strongly with AD severity: high FLT1 levels are associated with increased Aβ burden and worse cognitive performance, while FLT4 upregulation is linked to Aβ accumulation [54,62]. The gene discussed is FLT1; the disease is Alzheimer disease.