Conversely, hepatocyte-specific Rubcn knockout (Alb-Cre; RubcnF/F) mice exhibit enhanced autophagy, protecting against HFD-induced hepatic steatosis, liver damage, and ER stress, although these mice appear normal on standard chow, indicating Rubicon’s stress-specific regulatory function [230]. The gene discussed is RUBCN; the disease is Hepatic steatosis.