Overexpression of tRF-27 competitively binds to Ras GTPase-activating protein-binding proteins 1 and 2 (G3BPs) and activates the mechanistic target of rapamycin complex 1 (MTORC1) to enhance cell proliferation and induce the resistance of HER2-positive BC against trastuzumab [88]. Here, ERBB2 is linked to breast cancer.