tRF5-GlyGCC epigenetically upregulates Runx2 by interacting with histone 3 lysine 27 demethylase (KDM6B) and then transcriptionally activates integrin beta-like 1 (ITGBL1) and S100A9 expression in HCC cells, which further reduces NK cell cytotoxicity directly and attracts MDSCs to indirectly inhibit NK cell function [115]. This evidence concerns the gene ITGBL1 and hepatocellular carcinoma.