STAT6 and colorectal carcinoma: Specifically targeting the SPIB, 5′tiRNA-Gly-GCC regulates the promoter region of signal transducer and activator of transcription 6 (STAT6) and stimulates STAT6 transcription, as well as positively modulating the cJAK1/STAT6 signaling pathway, which collectively contributes to CRC progression [131].