Moreover, growing evidence has highlighted that methyltransferase-like protein-1 (METTL1) depletion causes the loss of m7G tRNA methylation and promotes the biogenesis of 5′ terminal oligoguanine-containing tRNA fragments (5′ TOGs), which regulate the activation of the interferon signaling pathway in cancer cells and transform the immunosuppressive prostate tumor microenvironment (TME) into a tumoricidal endotype, providing novel insights into PCa therapeutic strategies, particularly for patients with castration-resistant PCa [97]. The gene discussed is METTL1; the disease is cancer.