PPARGC1A and dry age related macular degeneration: We also identified several targets for PGC1α (PPARGC1A, peroxisome proliferator-activated receptor gamma coactivator 1-alpha), the loss of which compromises the RPE integrity, mimicking dry AMD [28,30] and we found that PGC1α represses gene expression in iPSCs compared to differentiated RPE while acting, instead, as an activator in committed RPE precursors compared to differentiated RPE (*all.summary.xls).