ZEB1 and cancer: Pleiotropic targets that are evoked during inflammatory and degenerative conditions of the RPE, such as binding sites for the predicted EMT drivers SNAIL1/2, TWIST1, ZEB, and bHLH family members, may provide potential avenues to address subretinal fibrosis in nvAMD, proliferative diabetic retinopathy, and, potentially, chemoresistance in cancer via pharmacogenomic, targeted therapies.