POU2F1 (OCT1) was footprinted on genes involved in endothelial cell differentiation, including ROCK1, an effector of Rho involved in cell polarity and cytoskeleton remodeling, activated by hyperglycemia and a possible target in diabetic retinopathy, IKBKB (−1340, TSS), an activator of the NFKB signaling pathway, and ADD1 (+827, TSS), involved in cytoskeleton regulation. This evidence concerns the gene POU2F1 and diabetic retinopathy.