Besides the histone deacetylases HDAC4, HDAC7, and HDAC11, we pinpoint previously uncharacterized epigenetic factors that could be involved in the pathogenesis of AMD, such as the transcriptional repressor SIN3A, the enhancer mediator protein MED1, the histone acetyltransferases HAT1, BRD2, and BRD4, the chromatin scaffold protein WDR5, and the methyltransferase and chromatin repressor SETDB1. This evidence concerns the gene SETDB1 and age-related macular degeneration.