Specifically, high CRP concentrations suggest that excess body weight may contribute to a state of chronic low-grade inflammation in children, potentially increasing the risk of developing various future health issues, such as cardiovascular disease and diabetes, through several pathways (e.g., reduced insulin sensitivity, increased release of adhesion molecules by the blood vessel lining, and higher production of clotting factors like fibrinogen in the liver) [30]. The gene discussed is INS; the disease is cardiovascular disorder.