The ten most significant DEPs between patients with NPC and healthy controls were Immunoglobulin heavy constant gamma 2 (IGHG2), Beta-Ala-His dipeptidase (CNDP1), Fumarylacetoacetase (FAH), Alpha-1-antichymotrypsin (AACT), also known as SERPINA3, CD5 antigen-like (CD5L), Apolipoprotein A-II (APOA2), Immunoglobulin heavy variable 3/OR16-12 (IGHV3OR16-12), Serum amyloid A-1 protein (SSA1), C-reactive protein (CRP), and Immunoglobulin heavy constant gamma 1 (IGHG1) (Table 1 and Supplementary Material Table S4). The gene discussed is SPRR2A; the disease is nasopharyngeal carcinoma.