UMAP clustering revealed a heterogeneous tumor microenvironment composed of malignant epithelial cells, fibroblasts, myofibroblasts, endothelial cells, CD8+ T cells (including exhausted CD8Tex), B cells, plasma cells, mast cells, monocytes/macrophages, and proliferating T cells (Supplementary Figure S7a). This evidence concerns the gene CD8A and neoplasm.