In bladder cancer (BLCA), NSUN2, IGF2BP2, YTHDC1, ALKBH5, TRDMT1, and ZC3H13 were identified, with NSUN2—a 5-methylcytosine (m5C) writer—previously shown to promote tumorigenesis and cancer stemness by stabilizing CCND1 mRNA and driving epithelial–mesenchymal transition. The gene discussed is IGF2BP2; the disease is bladder transitional cell carcinoma.