One of the main destructive factors for both OA and RA is the increased production of proteases MMP by metabolically active chondrocytes and FLS, induced by pro-inflammatory cytokines IL-1β and TNF-α, which degrade the ECM components of hyaline cartilage such as MMP-1, -3, and -13 [182,183]. Here, TNF is linked to rheumatoid arthritis.