NFKB1 and rheumatoid arthritis: Suppression of NF-κB signaling is relevant in both OA and RA, as there are cross-effects between the increased intracellular signaling via NF-κB, leading to the induction of MMPs, whose excessive secretion creates a catabolic microenvironment associated with more pronounced destruction of the ECM components in the cartilage tissue [186,187].