In a patient diagnosed with AML with myelodysplasia-related changes (AML-MRC) carrying adverse-risk mutations in U2AF1 and BCOR (Patient 1, Table 1), OGM detected a partial duplication of the KMT2A gene at 11q23, with a variant allele frequency (VAF) of 86%, consistent with KMT2A-PTD. The gene discussed is KMT2A; the disease is acute myeloid leukemia.