In mice with endotoxemia subjected to VT = 30 mL/kg, 4-PBA prevented the activation of GRP78, phospho-IRE1α, phospho-PERK, and ATF-6 induced by MV with VT = 30 mL/kg (Figure 2E–H). The gene discussed is HSPA5; the disease is serum lipopolysaccharide activity.