Interestingly, in a model of MGO-induced cytotoxicity in adherent neuroblastoma 2a (N2a), the combination of trans-resveratrol and hesperidin (tRES-HESP) significantly elevated the IL-10 levels in serum while restoring the GLO 1 protein levels in N2a cells [72,73], suggesting that elevation of IL-10 levels together with increased GLO 1 activity may represent a protective mechanism mediated by empagliflozin in conditions where the MGO levels are elevated, aiming to maintain the immune homeostasis. Here, TMPRSS11A is linked to neuroblastoma.