GPX4 and acute myeloid leukemia: These chemokine-mediated effects may be relevant for the resistance to the cytotoxic agent daunorubicin (an anthracycline) that increases reactive oxygen species and lipid peroxidation of AML cells, and these initial events are accompanied by SLC7A11/GPX4 inhibition together with increased intracellular free iron with mitochondrial damage and induction of programmed cell death [314].