Cytokines derived from T cells [69] (including IL4/IL10/IL13) and AML cells [70] can possibly contribute to M2 macrophage differentiation [68,70] and facilitate a switch from M1- to M2-like macrophages that support AML cells through various mechanisms [71,72,73], including a mitochondrial transfer leading to metabolic reprogramming [73]. The gene discussed is IL10; the disease is acute myeloid leukemia.