CXCL8 and acute myeloid leukemia: Many other proteins can also be classified as acute-phase proteins according to their variation, for example, in AML patients with febrile neutropenia, including several interleukins and chemokines, hematopoietic growth factors (e.g., G-CSF, GM-CSF and thrombopoietin), various proinflammatory cytokines (IL1β, IL6, IL8/CXCL8, TNFα and IFNγ) as well as soluble cytokine antagonists/receptors (i.e., IL1RA, soluble TNF receptors and soluble IL4Rα), soluble adhesion molecules (e.g., selectins, ICAM-1 and CD14) and soluble matrix molecules (e.g., endocan) [113].