We observed that C-C motif chemokine ligand 2 (CCL2), interleukin (IL)-18, and interleukin (IL)-33 were elevated in the circulation of patients with either acute infection (a-HBV) or early cirrhosis (cir-HBV), in contrast to healthy individuals (HI) (Figure 1A–C). The gene discussed is CCL2; the disease is Cirrhosis.