As previously reported, Kaosheng Lv et al. (2021) observed an upregulation of pFLT3 in MV411 cells upon disruption of FLT3-ITD palmitoylation through depletion of the palmitoyl acyltransferase ZDHHC6, which contributed to the progression of FLT3-ITD-mutant AML in mice [4]. The gene discussed is ZDHHC6; the disease is acute myeloid leukemia.