Among premenopausal cases, ER + BC that harbored the CC genotype exhibited the elevated rates of CTCF and HOXB13 alterations (p < 0.05 and p < 0.01, respectively), as well as CNAs in H3F3B, JAK3, and XPC (all p < 0.05; ** p < 0.001 for H3F3B and XPC) (Figure 3A and Supplementary Table S3). This evidence concerns the gene HOXB13 and breast cancer.