ALOX5 and rheumatoid arthritis: Higher levels of the two pro-inflammatory 12-lipoxygenase (12-LOX) products 11-HDoHE and tetranor-12-HETE (the main 12-HETE metabolite), as well as the pro-inflammatory 5-lipoxygenase (5-LOX) product 8-HETrE, were observed in patients with RA or OA than in healthy participants (Supplementary Figure S1).