RARRES2 and leukodystrophy: Our paper reports several novel findings: (1) SOP is significantly and independently associated with plasma levels of adipokines, specifically chemerin, inflammation index, SII, lipid profile (TC/HDL-C ratio), and body composition characteristics (ECW); (2) SOP, in turn, is a significant risk factor contributing to the likelihood of being associated with HTN, HLD, and T2D.