Therefore, in this study we aimed to determine the antibody profile occurring in SSc and MCTD among patients hospitalized at the Department of Rheumatology and Internal Disease of the Poznan University of Medical Sciences from 2005 to 2017 and the correlation of the presence of individual ANA and aPL antibodies with the incidence of LF and PH. This evidence concerns the gene FASLG and systemic sclerosis.