Interestingly, other studies have described A2AR’s control of synaptic transmission and modulation of glutamate excitotoxicity, and A2ARs have been suggested to be a potential target for many neurodegenerative disorders [22], including temporal lobe epilepsy [53], Parkinson’s disease [6], Alzheimer’s disease [54,55], and stress-induced LTP deficits [56]. This evidence concerns the gene ADORA2A and Alzheimer disease.