VEGFA and cancer: In cancer cells, IGF-1R plays a decisive role in contributing to the promotion of tumor growth by inhibiting apoptosis [34], transformation, metastasis [35] and the induction of angiogenesis in breast cancer through activation of S100A7 (the S100 calcium-binding protein A7)/RAGE (Receptor for Advanced Glycation End Products), which is associated with increased vascular endothelial growth factor (VEGF), so that inactivation of this factor would cause the inhibition of tumor cell growth [36].