Protein-derived inflammatory markers like C-reactive protein (CRP), albumin, fibrinogen, lactate dehydrogenase (LDH), beta-2 microglobulin (β2M), and interleukins (ILs) play an important role in assessing the inflammatory state of DLBCL, influencing prognosis, treatment decisions, and disease monitoring. The gene discussed is CRP; the disease is diffuse large B-cell lymphoma.