Statistical analysis showed that ovarian cancer patients in the total group had significantly higher levels of most of all of the tested MMPs (median MMP-7: 4.48 ng/mL; MMP-26: 9085.0 ng/mL; MMP-10: 95.45 ng/mL) as well as CA125 (313.55 U/mL) and HE4 (131.35 U/mL), compared to healthy women group (0.95 ng/mL; 7162.5 pg/mL; 49.54 ng/mL; 16.9 U/mL; 39.51 U/mL; p < 0.0001; p < 0.0001; p < 0.0001; p < 0.0001; p < 0.0001, respectively). This evidence concerns the gene WFDC2 and ovarian cancer.