Our study showed higher levels of both CA125 and HE4 in ovarian cancer patients (CA125: 313.55 U/mL; HE4 131.35 U/mL) compared to BL women (CA125 23.75 U/mL; HE4: 51.30 U/mL) and healthy women (CA125: 16.9 U/mL; HE4: 39.51 U/mL). This evidence concerns the gene WFDC2 and ovarian cancer.