Similarly, mammalian target of rapamycin (mTOR) inhibitors also produce hypomagnesemia in rats [102], which would be mediated, at least partly, by inhibition of epidermal growth factor (EGF)-induced regulation of TRPM6 expression, as demonstrated by in vitro studies in renal tubular epithelial cells [103]. The gene discussed is MTOR; the disease is familial primary hypomagnesemia.