In a prospective cohort of DLBCL patients, the concentrations of PEVs, including E-selectin+ EVs, P-selectin+ EVs, TF+/CD20+ EVs, TF−/CD19+ EVs, TF−/CD45+ EVs, and TF−/CD20+ EVs, were significantly higher compared to those in healthy controls. This evidence concerns the gene PTPRC and diffuse large B-cell lymphoma.