In conclusion, patients with DLBCL have increased concentrations of distinct EV populations, particularly PEVs, E-selectin EVs, P-selectin EVs, TF+/CD20+ EVs, and TF− DLBCL/B-cell EVs (CD19, CD20, CD45), compared to healthy controls. The gene discussed is SELP; the disease is diffuse large B-cell lymphoma.