Significantly higher concentrations of E-selectin+ EVs, P-selectin+ EVs, TF+/CD20+ EVs, TF−DLBCL/B-cell EVs (CD19, CD20, CD45), and TF−/CD20+ EVs were found in the DLBCL patients in comparison to healthy controls. Here, SELP is linked to diffuse large B-cell lymphoma.