The concentrations of PEVs, E-selectin+ EVs, P-selectin+ EVs, TF+/CD20+ EVs, TF−/CD19+ EVs, TF−/CD45+ EVs, and TF−/CD20+ EVs were significantly higher in DLBCL patients compared to healthy controls (p = 0.018, p = 0.008, p = 0.042, p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively). This evidence concerns the gene CD19 and diffuse large B-cell lymphoma.