Notably, EZH2 inhibitors, such as GSK126, promote apoptosis in GBM cells by inducing autophagy via the EZH2/miR-101/mTOR signaling axis—EZH2 knockdown upregulates miR-101, which regulates EZH2 in a positive feedback loop, further enhancing autophagy-mediated apoptosis. This evidence concerns the gene MTOR and glioblastoma.