GPX4 and glioblastoma: In GBM, the regulation of ferroptosis, a form of programmed cell death driven by iron-dependent lipid peroxidation, involves key epigenetic mechanisms, particularly the m6A RNA modification governed by the methyltransferase-like 3 (METTL3)/methyltransferase-like 14 (METTL14) complex, which modifies transcripts of genes such as glutathione peroxidase 4 (GPX4).