PRKDC and glioblastoma: Harvey Rat Sarcoma Viral Oncogene Homolog (HRas) is a member of the RAS protein family and is frequently activated in GBM, where the HRasV12 mutation activates the phosphorylated adaptor for RNA export (PHAX), which upregulates U3 small nucleolar RNAs (U3 snoRNAs) and recruits the Ku-dependent DNA-dependent protein kinase catalytic subunit (DNA-PKcs).