Gene-edited DMD iPSCs with a DMD knock-in that connected exon 44 directly with exons 58–70 were found to differentiate into the dystrophin-expressing myotubes both in vitro and after transplantation into mdx (DMD model) mice [294], and similar results have been achieved by deleting exons 48–54, which resulted in the functional beating iPSC-derived cardiomyocytes [295]. Here, DMD is linked to Duchenne muscular dystrophy.