A recent study also tested a twin prime editing strategy using the PEmax and recently evolved PE6 prime editors and dual prime editing guide RNAs flanking COL7A1 exon 5 in iPSCs from patients with recessive dystrophic EB (RDEB) caused by a deletion (c.553C>T) in COL7A1. Here, COL7A1 is linked to recessive dystrophic epidermolysis bullosa.