CFTR and diabetes mellitus: The first group to address this question used streptozotocin to induce diabetes in transgenic mice that harbored the FABP-hCFTR transgene, where the intestinal promoter for rat fatty acid binding protein 2 directed expression of a human CFTR gene, and a targeted knock-out mutation of the murine CFTR homolog gene (Cftrtm1Unc Tg(FABPCFTR)-1Jaw/J).