Cytokine receptor-targeting chimeras (KineTACs) induce lysosomal degradation via cytokine-mediated internalization [28], Transferrin receptor-targeting chimeras (TransTACs) target membrane protein degradation [29], autophagy receptor-inspired targeting chimeras (AceTACs) degraders successfully targeted degradation of aggregation-pron proteins and protein aggregates [30], and Folate Receptor-Targeting Chimeras (FRTACs) selectively degrade both soluble and membrane-bound cancer-related proteins efficiently [31]. Here, TFRC is linked to cancer.