Tumors harboring these cells are significantly associated with larger tumor size (p = 0.001), higher nuclear grade (p = 0.001), advanced tumor-node-metastasis (TNM) stage (p = 0.005), presence of coagulative necrosis (p = 0.027), and sarcomatoid differentiation (p = 0.008) compared to tumors lacking PD-1-positive TILs [32]. The gene discussed is PDCD1; the disease is neoplasm.