Ryanodine receptor type-1 (RYR1) is crucial for Ca2+ release from the sarcoplasmic reticulum (SR), and RYR1 dysfunction may contribute to impaired Ca2+ signalling; the result of the study suggests that Ca2+ signalling dysregulation, potentially involving RYR1, may contribute to respiratory and locomotor muscle dysfunction in COPD [48]. The gene discussed is RYR1; the disease is chronic obstructive pulmonary disease.