BCL6 Corepressor (Bcor) loss drives alterations in the B-cell compartment, promotes the transformation of CLL into aggressive lymphoma, and frequently co-occurs with mutated NOTCH1 which is a hallmark of RT, suggesting the therapeutic potential of targeting Bcor and NOTCH1 in RT [64]. The gene discussed is BCOR; the disease is B-cell chronic lymphocytic leukemia.