The deletion of NFAT2 gene in B cells accelerates CLL and resembles RT disease in Eμ-TCL1 transgenic mice, primarily due to the preferential use of certain VDJ recombinations (Variable, Diversity, Joining recombinations) and the selection of unmutated BCR, leading to oligoclonal disease [62]. Here, BCR is linked to B-cell chronic lymphocytic leukemia.