NFKB1 and B-cell chronic lymphocytic leukemia: Interestingly, in line with the essential role of NF-κB signaling in reprograming the microenvironment in CLL disease [86], IT-901 could also inhibit NF-κB signaling in microenvironmental supportive cells, including HS-5 stromal cells and nurse-like cells (NLCs), and disrupt their tumor-promoting phenotype by suppressing the expression of integrin genes in supporting cells [79].