At diagnosis CLL is characterized by complex karyotype aberrations, the most frequent being partial deletions at 13q (~55%), 11q (~15%), 17p (~8%), gain of chromosome 12 (~15%), and by mutations at different genes including TP53, SF3B1, BIRC3, NOTCH1, and ATM [3,4]. Here, TP53 is linked to B-cell chronic lymphocytic leukemia.