To verify whether the changes in antioxidant defense and the oxidative damage accumulation observed in the OSU and MEC-1 cell lines also occurred in cells isolated from CLL patients clustered based on the presence of wt or mutant p53, the intracellular levels of GSH and the cellular antioxidant capacity, as well as the MDA content, were evaluated in the presence of CpG-ODN/IL-15. The gene discussed is IL15; the disease is B-cell chronic lymphocytic leukemia.