ADM and gastric cancer: In gastric cancer (GC) cells, ADM silencing decreases the expression of phosphor-AKT (p-AKT), inhibiting the AKT signaling pathway, downregulating the anti-apoptotic protein Bcl-2, and upregulating the pro-apoptotic proteins cleaved-caspase-3 and Bax, which significantly reduces GC growth and promotes GC cell apoptosis [71].