MMP2 and familial pancreatic carcinoma: The research on pancreatic cancer revealed that treatment with ADM resulted in the phosphorylation of p38, Erk1/2, AKT, and eNOS, thereby enhancing the migration and invasion of bone marrow monocytes through the activation of the MAPK, PI3K/AKT, and eNOS signaling pathways, as well as increasing the levels of matrix metalloproteinases-2 (MMP-2) [79].