PGP and Focal cortical dysplasia: Therefore, Sisodiya et al. analyzed P-gp’s expression in ASM-naïve patients with malformations of cortical development and found that P-gp was overexpressed in glial cells and reactive astrocytes of the epileptogenic tissue of patients with dysembryoplastic neuroepithelial tumors, hippocampal sclerosis, and focal cortical dysplasia [74].