In comparison to HPV-positive cases, a poor prognosis usually has been documented among patients with HPV-negative cervical cancer, and the pathological processes of HPV-negative malignancy have been recorded to be linked with a number of mutated genes, decreased DNA methylation, and disruptions in cell signaling that include WNT/β-catenin, Sonic Hedgehog, and phosphatidylinositol 3-kinase (PI3K) pathways [37,82,83]. This evidence concerns the gene PIK3CA and cervical cancer.