For example, ferulic acid administration (150–300 mg/kg/day) in rats with fructose/STZ-induced diabetes significantly reduced blood glucose levels, increased serum insulin concentrations, enhanced antioxidant defenses (e.g., glutathione, superoxide dismutase (SOD), and catalase), and preserved pancreatic morphology and β-cell ultrastructure, as evidenced by histological and transmission electron microscopy analyses [111]. The gene discussed is INS; the disease is diabetes mellitus.