For facilitating viral infection and replication, several SARS-CoV-2 proteins have been shown to antagonize IFN-activated signaling, such as NSPs (NSP1, 6, 13, 14), structural proteins (M, N), and accessory proteins (ORF3a, 6–8) [8,9,11,20,21,25,26,27,28]. The gene discussed is SH2D3A; the disease is viral infectious disease.