CHRNA4 and sleep-related hypermotor epilepsy: We have already detected epileptic seizures resembling ADSHE/SHE seizures in genetic ADSHE rat models, so-called “S286L-TG” and “S284L-TG”, bearing rat missense S286L-mutant Chrna4, which corresponds to the S284L mutation in human CHRNA4 [1,10,11].