Section 6 (Oleocanthal’s Modulation of PAR-2 Signaling and Calcium Homeostasis in Colorectal Cancer): Focusing on colorectal cancer (CRC), this section explores our recent findings on OC’s ability to selectively inhibit Protease-Activated Receptor 2 (PAR-2) expression and restore intracellular calcium homeostasis, thereby attenuating key inflammatory and tumorigenic processes in CRC models. The gene discussed is F2RL1; the disease is colorectal cancer.