In cancer biology, NLRP3 exhibits a dual role: it promotes tumor progression in breast, lung, and gastric cancers by fostering chronic inflammation, angiogenesis, and immunosuppression, while suppressing tumor growth in colorectal and hepatic malignancies through the pyroptosis-driven elimination of malignant cells and activation of anti-tumor immunity [127,128]. Here, NLRP3 is linked to neoplasm.