OC’s disruption of the COX-2/mPGES-1 axis reverses PGE2-mediated immunosuppression by downregulating PD-L1 expression on tumor cells (40% reduction in TNBC) and inhibiting myeloid-derived suppressor cell (MDSC) recruitment via CXCL12/CXCR4 axis blockade [95]. This evidence concerns the gene PTGES and neoplasm.