The KEGG pathway enrichment analysis, visualized as a bubble map (Figure 4F), identified 184 pathways, with the top 10 signaling pathways being the renin-angiotensin system, neuroactive ligand-receptor interaction, endocrine resistance, human cytomegalovirus infection, renin secretion, thyroid cancer, VEGF signaling pathway, arachidonic acid metabolism, thyroid hormone signaling pathway, and platelet activation. The gene discussed is VEGFA; the disease is thyroid cancer.