The KEGG pathway enrichment analysis, visualized as a bubble map (Figure 4F), identified 184 pathways, with the top 10 signaling pathways being the renin-angiotensin system, neuroactive ligand-receptor interaction, endocrine resistance, human cytomegalovirus infection, renin secretion, thyroid cancer, VEGF signaling pathway, arachidonic acid metabolism, thyroid hormone signaling pathway, and platelet activation. Here, REN is linked to thyroid cancer.