ACE and metabolic syndrome: Furthermore, in T2D, the upregulation of the ACE1/Ang II arm in adipose tissue has been shown to promote triglyceride metabolism and dyslipidemia, which affects not only HDL availability, total cholesterol, and TG4s, but also causes and increases in low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL) [71,72].