In T2D, due to the increase in Ang II production in conjunction with a decrease in ACE2, which converts Ang II into Ang 1-7, there is insulin resistance and a decrease in adipokine production leading to overt hyperglycemia, which is evidenced by increased levels of glycated hemoglobin (HbAlc) [45,46]. The gene discussed is ACE2; the disease is type 2 diabetes mellitus.