ADIPOQ and prediabetes syndrome: The study highlighted a positive correlation between prediabetes, upregulation of RAS, and adipose tissue dysfunction, which resulted in ectopic fat redistribution [18,19]; however, the presence of RAS in the adipose tissue of humans with prediabetes and its relationship with associated adiposity biochemical and clinical markers, such as adipsin, cytokines, and adiponectin, has not been established.