Furthermore, seven gene sets (including apoptosis and KRAS signaling up) of the top ten enriched in high-TG2 HCC overlapped with all statistically significant gene sets enriched in the high-TGF-β1/high-TG2 HCC group (FWER p-value < 0.05). The gene discussed is TGFB1; the disease is hepatocellular carcinoma.