We demonstrate, in this study, that TG2 functions as a promoter for cell proliferation but not for cell migration ability in high-TG2 HCC cells (Figure 2) and suggest that the PI3K-Akt signaling pathway (Figure 3B) and the Wnt/β-catenin signaling pathway are potentially involved in the promotion of cell proliferation (Table 1). Here, AKT1 is linked to hepatocellular carcinoma.