A promising example is the ethyl ester of 3-bromomethyl-benzofuran-2-carboxylic acid (1, Figure 1), which was identified as a selective inhibitor of the PLK1-PBD (polo-box domain of polo-like kinase 1) and demonstrated activity against selected tumor cells both in vitro and in vivo [10]. The gene discussed is PLK1; the disease is neoplasm.