Lee et al. [116] found that Lactobacillus plantarum L-14 extracts (EPS) serve as an antioxidant in a mouse model of obesity induced by a high-fat diet, operating through the TLR2 and AMPK signaling pathways to inhibit the differentiation of adipose precursor cells to mature adipocytes, significantly alleviating obesity and related metabolic disorders. The gene discussed is TLR2; the disease is obesity due to melanocortin 4 receptor deficiency.