Why do GBP1 and GBP2 exhibit opposing roles across cancers—e.g., tumor suppression in colorectal cancer versus oncogenicity in glioblastoma—and can machine learning, multi-omics analysis, or systems biology predict these patterns from genomic, proteomic, or transcriptomic data [16,17,23,31,36]. This evidence concerns the gene GBP2 and colorectal cancer.