Genetic predisposition (such as family history, VDR gene polymorphism, and HLA-DRB1*15:01 allele), environmental factors (including Epstein–Barr virus infection, vitamin D deficiency, and smoking), sociodemographic characteristics (female, 20–40 years), and metabolic/behavioral factors (particularly obesity during adolescence and early adulthood) collectively contribute to the development of MS [10,11,12,13,14,15,16]. Here, VDR is linked to myeloid sarcoma.