After comparing PCa samples with normal tissues, the results indicated that upregulated (CCNB1, CCNA2, ESPL1, NCAPH, RAD54L, MELK, NCAPG) and downregulated (BUB1B, CDC20, CCNB1, AURKA, CENPE, UBE2C, TOP2A, CCNB2) genes were associated with PCa carcinogenesis, high Gleason scores ≥ (4 + 3), and age ≥ 55 years. This evidence concerns the gene RAD54L and posterior cortical atrophy.