We validated hub genes (NCAPG, MKI67, CCNA2, CCNB1, CDK1, CCNB2, AURKA, UBE2C, BUB1B) and their associated TFs (MYC, E2F4, YBX1) within the aggressive PCa pathway, particularly among older patients. Here, AURKA is linked to posterior cortical atrophy.