We validated hub genes (NCAPG, MKI67, CCNA2, CCNB1, CDK1, CCNB2, AURKA, UBE2C, BUB1B) and their associated TFs (MYC, E2F4, YBX1) within the aggressive PCa pathway, particularly among older patients. The gene discussed is CCNA2; the disease is posterior cortical atrophy.