The results show 27 Seed Entities with the most genomic alterations in PCa and included hub genes (AR, UBE2C, TOP2A, UBE2C, CCNA2, CENPE), TFs (MYC, E2F4, YBX1), and signaling pathways (PI3K-AKT, PIP3, P53, FoxO). This evidence concerns the gene E2F4 and posterior cortical atrophy.