After comparing PCa samples with normal tissues, the results indicated that upregulated (CCNB1, CCNA2, ESPL1, NCAPH, RAD54L, MELK, NCAPG) and downregulated (BUB1B, CDC20, CCNB1, AURKA, CENPE, UBE2C, TOP2A, CCNB2) genes were associated with PCa carcinogenesis, high Gleason scores ≥ (4 + 3), and age ≥ 55 years. Here, CCNB1 is linked to posterior cortical atrophy.