Our study indicates a significant positive prognostic influence of upregulated (NCAPH, RAD54L, E2F7, NDC80, MELK, ESPL1, MKI67, CCNA2, NCAPG) and downregulated (TOP2A, CCNB1, CCNB2, AURKA, UBE2C, CCNB1, KIF15, RAD54L, CENPE, CDC20) genes associated with the majority of the tumor-infiltrating immune cells, also indicating the above genes as potential biomarkers which are primarily expressed in PCa cells. This evidence concerns the gene TOP2A and posterior cortical atrophy.