We validated hub genes (NCAPG, MKI67, CCNA2, CCNB1, CDK1, CCNB2, AURKA, UBE2C, BUB1B) and their associated TFs (MYC, E2F4, YBX1) within the aggressive PCa pathway, particularly among older patients. This evidence concerns the gene CCNB2 and posterior cortical atrophy.