The results show 27 Seed Entities with the most genomic alterations in PCa and included hub genes (AR, UBE2C, TOP2A, UBE2C, CCNA2, CENPE), TFs (MYC, E2F4, YBX1), and signaling pathways (PI3K-AKT, PIP3, P53, FoxO). The gene discussed is AKT1; the disease is posterior cortical atrophy.