The results show 27 Seed Entities with the most genomic alterations in PCa and included hub genes (AR, UBE2C, TOP2A, UBE2C, CCNA2, CENPE), TFs (MYC, E2F4, YBX1), and signaling pathways (PI3K-AKT, PIP3, P53, FoxO). Here, TOP2A is linked to posterior cortical atrophy.