After comparing PCa samples with normal tissues, the results indicated that upregulated (CCNB1, CCNA2, ESPL1, NCAPH, RAD54L, MELK, NCAPG) and downregulated (BUB1B, CDC20, CCNB1, AURKA, CENPE, UBE2C, TOP2A, CCNB2) genes were associated with PCa carcinogenesis, high Gleason scores ≥ (4 + 3), and age ≥ 55 years. The gene discussed is CCNA2; the disease is posterior cortical atrophy.