We validated hub genes (NCAPG, MKI67, CCNA2, CCNB1, CDK1, CCNB2, AURKA, UBE2C, BUB1B) and their associated TFs (MYC, E2F4, YBX1) within the aggressive PCa pathway, particularly among older patients. This evidence concerns the gene MYC and posterior cortical atrophy.