To this end, we used a variety of Medical Subject Headings (MeSHs) and free-text keywords, including “inflammasome”, “NLRP3”, “cardiovascular diseases”, “atherosclerosis”, “heart failure”, “pericarditis”, “pyroptosis”, “IL-1β”, “IL-18”, and “targeted therapy”. The gene discussed is NLRP3; the disease is atherosclerosis.