Consequently, serum levels of ZAG have been reported to be significantly decreased in subjects with obesity, showing negative correlations with anthropometric measures such as BMI, waist circumference, waist-to-hip ratio, body fat percentage, and triglycerides, while positively correlating with HDL cholesterol and adiponectin [3,28,29,30]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.